This week we are talking about nanoparticles that perform two or more functions
ID: 58068 • Letter: T
Question
This week we are talking about nanoparticles that perform two or more functions in the body. Your challenge is to think about how to design a multi-modal nanoparticle for your disease of interest think about what is the strongest chemical need should u develop nanoparticle that treats your disease at the same time in to two different ways or would u like to able to diagnose and treats a disease at the same time or do u need more robust to measure when her a treatment is working (treatment monitoring)? Please explain the biological problem you are trying to solve and how you would go about designing one or more nanoformulations to solve this problem And remember, you are welcome to use the literature for ideas!Explanation / Answer
For diagnosis of malaria, use of labelled antibodies with gold nanoparticles are used that can detect the lysed malarial antigens. The labelled antigens bind to he parasites and can be detected easily by forming a visible band.
In a a needle-free method of diagnosing malaria. the parasites can form nanoparticles, called as hemozoins, in RBC, and using laser pulses, the vapour bubbles are generated from the hemozoins. When these bubbles burst, an acoustic signal generated only by these nanoparticles can then be quickly detected.
Treatment by nanoparticles can be initiated by targeting infected hepatocytes, merozoites, infected RBC, sporozoites, ookinetes and disrupting the pathogen by invading the gut.
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