You are in the jungle and feeling a bit hungry. You decide to snack on some of t

Question

You are in the jungle and feeling a bit hungry. You decide to snack on some of the local plants, as they look delicious. Unbeknownst to you, the plant you decide to eat contains a compound that acts as an inhibitor of phospholipase C activity. Soon after consuming your snack, you begin to hear a rustling in the leaves. You fear that it could be a large, carnivorous animal and thus choose to run. The epinephrine release, stimulated by your fight or flight response, leads to the activation of specific G protein-coupled receptors that stimulate the breakdown of macromolecules to generate the energy you need to run. What effect will the presence of the phospholipase C inhibitor have on your ability to escape the predator? Select all that apply. will prevent the formation of cAMP. It will prevent the formation of IP_3 It will prevent the formation of DAG. It will prevent the activation of PKA. It will likely inhibit some of the signaling pathway downstream of the GPCR activated by epinephrine. It will prevent the activation of the heterotrimeric G protein involved in the signaling pathway.

Explanation / Answer

The phospholipase C cleaves the phospholipid phosphatidylinositol 4,5-bisphosphate (PIP2) into diacyl glycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Here, IP3 is released as a soluble structure into the cytosol and DAG remains bound to the membrane.

So, if the inhibitor of phospholipase C inhibits the enzyme, then It will prevent formation of IP3, It will prevent formation of DAG, and it will likely inhibit the some signalling pathway downstream of GPCR of GPCR activated by epinephrine.

Thus, the correct options are (b), (c) and (e).

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