Lipophilic drugs are usually eliminated by Renal clearance involves Phase I enzy

Question

Lipophilic drugs are usually eliminated by Renal clearance involves Phase I enzymes ·roximately 80% after intravenous administration or a drug For questions 11-14 250 mg of a drug ncentrations ons at variouent weighing 70 kg by intravenous bolus administration and the drug times sh C-1.79 mgliter e own in the graph below can be described by the equation: 10 5 S 0.1 0 2 4 6 8 10 12 14 16 18 20 22 24 Time, h 11. The half-life (tw) of this drug is: a. 1 hours b. 6 hour 12 hours 24 hours 12. The clearance (CL) of the drug is: 8 liters/hour ters/hour d. 24 liters/hour The volume of distribution (V) of the drug is: a. 1 liters/kg 13 13. 2 liters/kg c. 4 liters/kg d. 4 liters d the MTC is 20 mg/L. The next dose of this drug should be administered 14. The MEC for the drug is 0.9 a. 2 hours after the first dose b. 8 hours after the first dose c. 12 hours after the first dose d. 24 hours after the first dose

Explanation / Answer

MEC = Minimum Effective Concentration of the drug .

MTC= Maximum Tolerate Concentration of the drug.

As the half life time of the drug is 12 hours and initial conc.of the drug is 1.79mg/L as calculated from given info.

After half life time half of the conc. Of the drug will be used and the conc. at t1/2 will be 1.79/2= 0.895mg/L ~ .90 mg/L which is the MEC.

SO ,next dose should be given after 12 hours of first administration.

Option C is correct .

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