Describ how the inhibitory transmembrane receptor protein on an immune cell is g

Question

Describ how the inhibitory transmembrane receptor protein on an immune cell is generated from a gene in the nucleus to the point where it inserts itself into the plasma membrane. The name of the inhibitory transmembane receptor is Reymar. You must include how it is:

1) transcribed and alternately processed in the nucleus,

2) translated in the cytoplasm

3) correctly targeted to the plasma membrane.

Please make it as long as possible, and very descriptive and nothing off the internet,essay like form, Thank you

Explanation / Answer

Generally inhibitory transmembrane receptor proteins like acetyl choline is a colinergic neurotransmitter synthesized from choline and acetyl-coA by enzyme choline acetyl transferase.

After synthesis it is released by the process of exocytosis in the synaptic cleft. enzyme acetyl cholinerase is a serine esterase present in synaptic cleft . Acetyl choline can produce excitatory response in some post synaptic cells and inhibitory response in others. Response is mediated by binding of acetyl choline with acetyl choline receptor present on post synaptic cell.These are the best understood ligand gated channels and is of two types nicotinic and muscarinic acetyl choline receptors.nicotinic belongs to excitatory class and muscarinic belongs to inhibitory .muscarinic transmembrane receptors proteins interact with G-proteins and the receptors get activated resulting in several effects .

when two molecules of acetyl choline binds to this receptor channel opens and conducts sodium ions resulting in membrane depolarization

Transport of proteins across a membrane from the cytosol into ER lumen , mitochondria is the transmembrane transport which is a receptor mediated transport . ligand binds to the receptor and move laterally till they reach pith region of membrane and coated proteins found on innersurface of plasma membrane is activated resulting invagination and coated vesicle. clatherin, dynamin or adaptor proteins are involved. once the coated vesicle enters inside uncoating ATP is activated which removes coat proteind to form another coated vesicle. Theuncoated vesicle fuses with early endosome and acidification of compartment results in loss of receptor of affinity of ligand. Receptor is transported by endocytosis .Endosomes mature into lysosomes and ligand is digested

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