26. The amino acid substitution of Val for Glu in Hemoglobin S results in aggreg

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26. The amino acid substitution of Val for Glu in Hemoglobin S results in aggregation of the protein because of interactions between molecules. A-covalent B. disulfide C. hydrogen bonding D. hydrophobic E. ionic 27. Which of the following statements is true about 2,3-Bisphosphoglycerate (2.3-BPG) regulating 02 binding with A 2,3-BGP is a small negatively charged molecule .238cpbids to the postively chargvHb C. 2,3-BGP stabilizes the T states E. all of the above 28. The phosphate buffer system is very important for maintaining the pH of the oytoplasm of all cels. Phosphoric acid is a biologically useful, neutrail range, with a pka of 6.86, is that of triprotic acid, however, the relevant equilibrium in the dihydrogen phosphate and monohydrogen phosphate ions (data from Table 26) Hassetakh equation (pH.pKa-HPA1cakiate the pH of a solton contaning 0.042 M Using the NaH2PO4 and 0.042 M Na2HPO4. A. 2.14 B. 6.86 C. 7.12 D. 12.4 E. None of the above Calculation, sketching and assay questions 29. Amino Acid Sequence and Protein Structure Our growing understanding of how proteins fold allows researchers to make predictions about protein structure based on primary armino acid sequence data. le-Ala-Hi-The-Tyr-Gly-Pao-Phe-Glu-Ala-Ala-Ma-Cys-Lys-Trp-Gil-Alia-Ga-Pro-Ap-Gly-Met-Gle-Cys-Ala-Phe-His-Arg 23456789 11 12 13141516 17 ss 19 .20 21 22 23 24 25 26 27 28 Consider the following amino acid sequence. (a) Where might bends or b turns occur? (4pts) (b) Where might intrachain disulfide cross-linkages be formed? (4pts) 30. The strongly polar hydrogen-bonding properties of water make it an excellent solvent for ionic (charged) species. By contrast, nonionized, nonpolar organic molecules, such as benzene, are relatively insoluble in water. In principle, the aqueous solubility of any organic acid or base can be increased by converting the molecules to charged species. For example, the solubility of benzoic acid in water is low. The addition of sodium bicarbonate to a mixture of water and benzoic acid raises the pH and deprotonates the benzoic acid to form benzoate ion, which is quite soluble in water C-0 Benzok acid Benzoale ion

Explanation / Answer

26.

Conversion of Glutamic acid ( polar) to valine (Hydrophobic) means a hydrophilic group is converting to a hydrophobic group.

This transfer of Polar to Hydrophobic on the surface reduces the solubility of the molecule and enhances the formation of large insoluble aggregates.

Therefore the answer of the question is option D. Hydrophobic

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