The following is true regarding cotranslational translocation: a hydrophobic cor
ID: 56473 • Letter: T
Question
The following is true regarding cotranslational translocation:
a hydrophobic core within the SRP binds to a hydrophobic region on the N-terminal side of the Signal Sequence
a hydrophillic core within the SRP binds to a hydrophobic region on the N-terminal side of the Signal Sequence
a hydrophillic core within the SRP binds to a hydrophillic region on the N-terminal side of the Signal Sequence
a hydrophobic core within the SRP binds to a hydrophillic region on the N-terminal side of the Signal Sequence
a hydrophobic core within the SRP binds to a hydrophobic region on the N-terminal side of the Signal Sequence
a hydrophillic core within the SRP binds to a hydrophobic region on the N-terminal side of the Signal Sequence
a hydrophillic core within the SRP binds to a hydrophillic region on the N-terminal side of the Signal Sequence
a hydrophobic core within the SRP binds to a hydrophillic region on the N-terminal side of the Signal Sequence
Explanation / Answer
cotranslational translocation is used by several proteins like secretory and membrane bound proteins or proteins that reside out of endoplasmic reticulum , golgibodies or endosomes. The initiation of process occurs by recognition of N - terminal signal peptide sequence which is a 6 - 12 hydrophobic residues that bind to hydrophobic core of signal recognition particle (SRP). Hence, option 1 is correct.
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