calculate the moles of ATP per gram for the complete aerobic metabolism of the f

Question

calculate the moles of ATP per gram for the complete aerobic metabolism of the following amino acids.

NOTE: Be sure to oxidize the amino acid all the way to CO2.

Don't stop when you get to a Krebs cycle intermediate -- go from oxaloacetate to PEP to pyruvate to acetyl-SCoA and then oxidize the acetyl-SCoA to CO2 by going around the Krebs cycle again.

Note: Whenever glutamate is produced in a transamination reaction, recycle it to -ketoglutarate (via the glutamate dehydrogenase reaction) and make ATP from the NADH.

a) alanine

b) arginine (assume that both dehydrogenases use NAD+, not NADP+, as an oxidizing agent)

c) tyrosine

d) isoleucine  

Explanation / Answer

a) Alanine is degraded via pyruvate. It is converted into pyruvateAcetyl coACitric acid cycle. A total of one ATP equivalent is synthesized at substrate level phosphorylation. 4 reduced NADH2 and one FADH2 are formed, which give 14 ATP. Altogether, oxidation of one gram of Alanine gives 15 gram moles of ATP.

d) Isoleucine is oxidized through methyl-butyryl coA pathway which generates two reduced powers and two acetyl coA. Each acetyl coA gives 12 ATP, and the two reduced powers generated during conversion of isoleucine to acetyl CoA gives 5 ATP. A total of 29 ATP are generated upon complete oxidation of isoleucine

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