You deduce the entire amino acid sequence for p77 from the sequence of your cDNA

Question

You deduce the entire amino acid sequence for p77 from the sequence of your cDNA. If p77contained one of the following amino acid sequences, what do you think these sequences might predict about the protein’s function and/or distribution in the cell?

(a) Lys-Lys-X-X

(b) Tyr-X-X-phi (where phi is a hydrophobic amino acid residue, and X is any amino acid residue)

(c) Lys-Asp-Glu-Leu

(d) Amphipathic helix, 20-50 residues in length, with Arg and Lys residues on one side and hydrophobic residues on the other

Explanation / Answer

a) Lys-Lys-X-X
(b) Tyr-X-X-phi (where phi is a hydrophobic amino acid residue, and X is any amino acid residue)
(c) Lys-Asp-Glu-Leu
(d) Amphipathic helix, 20-50 residues in length, with Arg and Lys residues on one side and hydrophobic residues on the other

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