1. You are designing a surface erodible polymer to fabricate a scaffold for tiss
ID: 555521 • Letter: 1
Question
1. You are designing a surface erodible polymer to fabricate a scaffold for tissue engineering. The polymer that you develop does not allow long-term cell attachment, which is an essential requirement for the application. You then propose a modification method through covalently binding cell- adhesive peptide to the polymer. Your group mate suggests that you should bind the cell-adhesive peptide to the surface of the polymer scaffold since that allows the exposure of the peptide for cell recognition and binding. Will your group mate's idea work to achieve long-term cell attachment to your scaffold? If this is not a viable idea, please suggest alternative approach to make the polymer scaffold cell-adhesive for long term. (4 points)Explanation / Answer
Polimer scaffolds play an important role in three dimensional cell culture and tissue engineering. to best mimic the architecture of natural extracellular Matrix nanofibrous and micro porous combined scaffolds, which can be prepared by combining a phase separation and particulate lesching techniques, can be used for cell adhesive for long term. Several research articles has been published on this technique.
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