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Lipid composition varies across membrane compartments as well as across membrane

ID: 55540 • Letter: L

Question

Lipid composition varies across membrane compartments as well as across membrane leaflets. What mechanism is key to enrich phosphatidylcholine in exoplasmic leaflets? Choose the best answer. Transfer of lipid delivered by vesicle membrane trafficking. Transfer of lipid delivered by direct contact between ER and cell membranes. Transfer of lipid delivered by a lipid binding protein that shuttles it through the cytosol. Diffusion across the bilayer. ATP powered flippases All of the above choices (A, B, C, D, E) are all possible contributors to leaflet asymmetry.

Explanation / Answer

E. ATP powered flippases.

The key mechanism to enrich phosphatidylcholine in exoplasmic leaflets is by ATP powered flippases. ATP powered flippases are the transmembrane lipid transporting enzymes located within the membrane.

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