cell biology question Hormones that use the tyrosine kinase receptor mechanism a

Question

cell biology question

Hormones that use the tyrosine kinase receptor mechanism as shown in the animation are important for paracrine control of one cell by an adjacent cell, rapid adaptation to physiological changes, regulation of cellular calcium levels, cellular growth and survival. Autophosphorylation is an important part of the mechanism of the receptor tyrosine kinases. Why is The phosphorylation causes the receptors to dimerize. The phosphorylation activates the kinase domain. The phosphorylation causes down regulation of the receptors. The phosphorylation provides sites for recruitment of other signal transduction molecules. Sos activates Ras. Sos is an example of a tyrosine kinase. GTPase-activating protein (GAP), protein with an SH2 domain, guanine-nucleotide exchange factor (GEF).

Explanation / Answer

The correct answers are

Part C

guanine-nucleotide exchange factor (GEF).

Sos is an example of guanine-nucleotide exchange factor (GEF).

Guanine nucleotide exchange factors (GEFs) activate monomeric GTPases by the release of guanosine triphosphate (GTP). The sos refers to the son of sevenless which are a set of genes encoding guanine nucleotide exchange factors. These act on the GTPases.

Part D

The correct answer is

a mutation in Ras that makes it unable to hydrolyze GTP

Part E

The correct answer is : it is able to dimerize with a functional receptor without the activation of autophosphorylation.

Part A

The correct answer is : cellular growth and survival.

Part B

The correct answer is : The phosphorylation provides sites for recruitment of other signal transduction molecules

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