[Polymeric nanoparticles, Ceramic nanoparticles: Describe how these nanoparticle

Question

[Polymeric nanoparticles, Ceramic nanoparticles:

Describe how these nanoparticles are designed to function in the human body. What physical properties of your nanoparticles will you need to test in vitro to optimize these nanoparticles? What are the ideal characteristics you are aiming for? What tests will you use to determine how close you are to meeting your ideal characteristics? What would you change about your nanoparticles if they don’t perform like they are supposed to?No less than 500 words

Explanation / Answer

These nanopartcles are designed to function in the human body by using various delivery systems. Formulating a delivery system helps ensure the ability of nanoparticle to bind or adsorb in the body locations and deliver the therapeutic or diagnostic effect they are assigned. Many nanoparticles work as drug delivery systems in the body.

The physical properties that need to be tested in vitro to optimize the nanoparticles are size, morphology, chemical composition, structure, biopersistance, tissue specificity and toxicity.

The ideal characteristics we aim for are as follows:

1. The nanoparticles should have a size range between 2nm to 1m for pharmaceutical purposes. Mainly the size and morphology is manipulated to ensure that the nanoparticles enter the body in a considerably fast manner.

2. For penetrating mucus barriers nanoparticles of large size such as 200nm show promising effect.

3. The structure and chemical composition of nanoparticle should be such that it can easily combine with the human body. It should not show any kind of negative reactions when delivered in the body.

4. Biopersistance of a nanoparticle should be such that once it delivers the drug or has served the desired purpose it should not persist or remain in the system for long. There must be an efficient manner in which the nanoparticle must leave the system.

5. The nanoparticles should be tissue specific. This means that they should function in the tissue assigned for delivery and do not metabolize or assimilate in the body before reaching the target destination. This is the reason that delivery route of nanoparticles differ from each other.

6. The nanoparticles should be non toxic in nature. Though some nanoparticles may show some side effects over time but nanoparticles which are toxic are outright rejected.

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