Question 3 (8 points) Consider the following mutations and, for each, explain wh

Question

Question 3 (8 points)

Consider the following mutations and, for each, explain whether

a) you expect it to be potentially promoting cancer AND

b) you expect it to be a dominant or recessive mutation.

i) A mutation that destroys the active site of an enzyme necessary to promote cell cycle

a)

b)

ii) A very premature STOP codon in a gene encoding a protein involved in the excision-repair mechanism

a)

b)

iii) A point mutation that renders constitutively active one of the signaling proteins in the Ras pathway

a)

b)

iv) A null mutation in a gene encoding an apoptotic (apoptosis-promoting) protein

a)

b)

Explanation / Answer

i) A mutation that destroys the active site of an enzyme necessary to promote cell cycle would be a dominant or recessive mutation and inhibits the cell cycle. Option b is correct.

ii) A very premature STOP codon in a gene encoding a protein involved in the excision-repair mechanism would be a dominant or recessive mutation and inhibits protein synthesis resulting in immature protein. Option b is correct.

iii) A point mutation that renders constitutively active one of the signaling proteins in the Ras pathway would result in potentially promoting cancer. Option a is correct.

iv) A null mutation in a gene encoding an apoptotic (apoptosis-promoting) protein would be a dominant or recessive mutation and does not alter the apoptosis activity. Option b is correct.

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