h HW5-Hemoglobin [Compatibility Mode] t References Mailings Review View BPG (bis
ID: 546354 • Letter: H
Question
h HW5-Hemoglobin [Compatibility Mode] t References Mailings Review View BPG (bisphosphoglycerate) is involved in the adjustment of Oxygen delivery at high altitude. Briefly explain how this works. 1. What is the highest possible value of the Hill coefficient for hemoglobin? Why? If hemoglobin actually had such a Hill coefficient, do you expect to find any partially liganded species when oxygen is present (e.g. [Hb-0l. [Hb-(0)], [Hb- (02)s])? Justify your answer. 2. 3. Consider the following plot of Myoglobin, Hemoglobin and a Hemoglobin mutant. a. What is the effect of the mutation on affinity? b. What is the effect of the mutation on cooperativity? Discuss how this change in cooperativity would affect oxygen delivery to the tissues by the mutant enzyme. You may find it useful to refer to the binding curves. Oxygen levels in the lungs are 80-100 torr, while those in the tissue are about 10-20 torm, c. Binding Curve D.9 0.8 0.7 0.6 0.4 0.3 0.2 0.11 50 102) torr100 MyO -+-Ho.normal -*-HE-mutarM 4. Compare adult and fetal hemoglobin using the following criteria, AND discuss the physiological importance of cach of the differences a. Subunit composition Focus -" F6 F3 F4 F5 F7 F9 F10Explanation / Answer
Ans 1 :
Hemoglobin is a protein that is present in the red blood cells of our body , which is responsible in the transport of oxygen all over the body. The BPG (2,3-biphospho glycerate) helps in stabilising the taut form of hemoglobin , due to which its tendency to bind with oxygen reduces.
Due to the presence of BPG , the hemoglobin becomes less saturated with oxygen at tissue levels , so that more of it can be supplied to them.
So the amount of BPG is usually observed more in people living at high altitudes.
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