One difference between miRNA and siRNA is: siRNA binds to semi-complementary str

Question

One difference between miRNA and siRNA is:

siRNA binds to semi-complementary strands of mRNA whereas miRNA bind to complementary strands of mRNA

miRNA binds to tRNA and siRNA binds to DNA

miRNA binds to semi-complementary strands of mRNA whereas siRNA bind to complementary strands of mRNA

There are no differences

siRNA binds to semi-complementary strands of mRNA whereas miRNA bind to complementary strands of mRNA

miRNA binds to tRNA and siRNA binds to DNA

miRNA binds to semi-complementary strands of mRNA whereas siRNA bind to complementary strands of mRNA

There are no differences

Explanation / Answer

miRNA binds to semi-complementary strands of mRNA whereas siRNA bind to complementary strands of mRNA.

This is a typical difference between miRNA and siRNA. miRNAs specilly those derived from animals have incomplete base pairing with the target and can inhibit the translation of many such mRNAs with similar sequence. In contrast, siRNAs typically base pair perfectly with the target mRNA and induce cleavage of the specific target.

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