You identify mutations in an unstudied human gene associated with a human respir

ID: 54198 • Letter: Y

Question

You identify mutations in an unstudied human gene associated with a human respiratory disease. You raise antibodies against the human protein encoded by this gene that you name, Wheezer. To better understand how Wheezer functions, you look at Wheezer expression in different cell types across human tissues as well as from other species. You find that the Wheezer antibody detects one protein of similar molecular weight in yeast, fruit flies, mice and humans. Your studies begin to point to a Wheezer role in regulating protein synthesis at the ER in response to cell stress. What is/are likely explanation(s) and consequences for the observations? The antibody to human Wheezer detects proteins with highly conserved amino acid sequence across evolution. It is likely that Wheezer has functions in a fundamental cellular process (so, has functions in cells beyond just those involved in human breathing). You can use the antibody made against human Wheezer to study its function and regulation in yeast, fly or mouse. It is possible that there are shared mechanisms in the regulation of protein synthesis at the ER in response to cell stress across eukaryotic species. Possible choices include just A and C. Possible choices include all of the above (A, B, C, D).

Explanation / Answer

Possible choice included all of the above explain the function of wheezer protein.

Reason being There is always possibility of having same conserved regions due to evolutionary relationship.As well as it is mandatory to check the effect of raised antibody in fly and mouse.

Then there is possibility of wheezer is also involved in the other cellular process, or shared mechanism in the regulation of protein synthesis in ERin response to cell stress because cells produce alternatives to withstand the stress.

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You identify mutations in an unstudied human gene associated with a human respir

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