Page 4: 3D protein structure, stability and folding. Please answer everything. (
ID: 539825 • Letter: P
Question
Page 4: 3D protein structure, stability and folding. Please answer everything. (16 pts) 13. Alpha keratin is a fibrous protein found in hair and nails. It consists of multiple peptide chains coiled together. (a) Please label the secondary and quaternary structure in the above image. (2 pts) (b) Thinking about the properties of hair and nails, which class of amino acids would you expect to see in an keratin primary sequence, and why (4 pts) e) Nails are much stronger and less flexible than hair. Thinking about the properties of amino acids that give "strength to tertiary and quaternary structure of proteins, which residue would you expect to be more prevalent in nails? Explain. (4 pts) (d) Fibrous proteins often have multiple peptide chains with repeating secondary structures. (6 pts) Name another type of fibrous protein What secondary structure is most prominent: Propose an amino acid sequence Bonus: Draw a cartoon of this protein (2 pts)Explanation / Answer
1. alpha helix is the main motif in the secondary structure. where as the super coiled alpha-helix is forms the quarternary structure.
2. the parimary structrure of alpha keratin typically has Alanine, Leucine, Arginine, Cystine.
3. cysteine greatly supports strength in mails. the dual bonding due to cysteine makes the nails more strong.
4.
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