Sapling Learning During exercise when the body lacks an adequate supply of oxyge

Question

Sapling Learning During exercise when the body lacks an adequate supply of oxygen to support energy production, the pyruvate that is produced from the breakdown of glucose is converted into lactate. High lactate levels can lead to acidity in the muscle cells as some of the lactate hydrolyzes to lactic acid. The dissociation of lactic acid to lactate is shown in the reaction below. L acid has a pKa of 3.86. actic H Lactate Lactic Acid A solution containing a mixture of lactic acid and lactate was found to have a pH of 4.27. Calculate the ratio of the lactate concentration to the lactic acid concentration in this solution. Number lactate lactic acid AO Previous Give Up & View Solution Check Answer Next Exit

Explanation / Answer

HC3H5O3 <-----> C3H5O3 + H+

Given- PH of solution = 4.27

The PKa of lactic acid is 3.86

We can calculate the ratio of the lactate concentration to the lactic acid concentration by using Henderson–Hasselbalch equation

PH = PKa + log [Lactate]/[Lactic acid]

4.27 = 3.86 + log [Lactate] /[Lactic acid]

log [Lactate]/[Lactic acid] = 0.41

[Lactate]/[Lactic acid] = 10^0.41

[Lactate]/[lactic acid] = 2.57

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