5. (10 points) Itis known that certain types of human cancer cells require an ab

Question

5. (10 points) Itis known that certain types of human cancer cells require an abnormally high concentration of asparagine. The enzyme asparaginase, (which is not naturally found in humans) can be used as a chemotherapeutic drug since it catalytically breaks down asparagine into aspartic acid and ammonia and thus suppresses the growth rate of the cancer cells. The normal asparagine concentration in human cells (and cancer cells is 2.0 x 103M. below, purified from Considering the catalytic properties of the enzymes shown asparaginase concentrations in bacterial strain would be the most effective drug for lowering asparagine human tissues? explain your answer. Bacterial Strain 4.6 x 102M 2.6 x 10-3 mmol Asn/min 3000 sec 1 Pseudomanas aeruginosa 1.1 x 10.3M 1.9 x 10.3 mmol Asn/min 2000 sec Bacillus subtilis 2.8 x 10-2M 2.9 x 10-3 mmol Asn/min 4000 sec 1 Escherichia coli

Explanation / Answer

Kcat is the turnover number of an enzyme. It defines that how fast an enzyme can function

so here E.coli has highest turn over number = 4000 sec-1

So this will be the fastest to lower the concentration of asparagine.

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