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1. A couple has a female child with Tay Sachs disease, and threeunaffected child

ID: 5296 • Letter: 1

Question

1. A couple has a female child with Tay Sachs disease, and threeunaffected children. Neither parent nor any of the four biologicalgrandparents of the affected child has had this disease. The mostlikely genetic explanation is that Tay Sachs disease is inheritedas a(n) ______________ disease.

A. autosomal dominant
B. autosomal recessive
C. sex-linked recessive
D. sex-linked dominant
E. cannot make a reasonable guess from this information

Please explain how to determine this (doesn't have to be long Ipretty much understand just want to check work.) thanks will rateasap.

Explanation / Answer

b) autosomal recessive.because the disease is recessive because bothparents are unaffected, and autosomal because a female child isaffected but her father is not.