. When studying the structure of protein P, you encountered a coiled-coil motif,

Question

. When studying the structure of protein P, you encountered a coiled-coil motif, formed when two alpha helices wrap around each other. The interaction between the two alpha helices involves interactions between hydrophobic residues. The sequence of the helices involved are: 1 Val – 2 Ala – 3 Ser – 4 Leu – 5 Ala – 6 Tyr – 7 Glu – 8 Val – 9 Ala – 10Leu – 11Ser – 12Ser – 13Tyr – 14Gln - 15Val 1 Val – 2 Ala – 3 Ser – 4 Leu – 5 Ala – 6 Tyr – 7 Glu – 8 Val – 9 Ala – 10Leu – 11Ser – 12Ser – 13Tyr – 14Gln - 15Val Assuming that these two helices form perfect helices, answer the following questions (mark true or false):

a. The distance from 1 Val to 15Val is 5.4 Å, the pitch of the helix. _________

b. The carbonyl of 2 Ala will form a hydrogen bond with the amino hydrogen of 5 Ala ______

c. If you exchange the position of 11Ser and 10Leu, the coiled coil motif would be stabilized. _________

d. If you replace 4 Leu with a Gly, each individual alpha helix will be stabilized. ______ e. If you replace 6 Tyr with Lys, the overall structure will be stabilized ________

f. If you replace 4 Leu with Gln, the coiled coil motif will fall apart. However, if you replace 5 Ala with Gln, the coiled coil motif will still form ________

Explanation / Answer

a. True

b. True

c. False

d. False

e. False

f. True

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