Which of the following forces would increase the formation of fluid in the tissu

Question

Which of the following forces would increase the formation of fluid in the tissue spaces (interstitial fluid)? Select ALL that apply.

A. vessel injury allowing escape of albumin into the tissue spaces

B. increased capillary permeability

C. increased blood flow to the tissue/increased tissue perfusion

D. Increased BOP

E. Increased BHP

A. vessel injury allowing escape of albumin into the tissue spaces

B. increased capillary permeability

C. increased blood flow to the tissue/increased tissue perfusion

D. Increased BOP

E. Increased BHP

Explanation / Answer

A. Vessel injury leads to escape of fluid into interstitial spaces and thus leads to an increase in the interstitial fluid.

B. Increased capillary permability increases the leakage of cell free plasme into surrounding tissue spaces, and thus leads to edema of that area, interstitial fluid increases.

C. Increased blood flow brings more blood than the capillaries can accommodate. Due to the thinness of capillary walls, which have a flip flop overlapping edges, they allow fluid leakage and thus it leads to an increase in interstitial fluid in tissue spaces.

D. Increased blood osmotic pressure reduces the difference in osmotic pressure between the interstitial spaces and the blood. Usually, osmotic pressure in the interstitial spaces is greater than the blood pressure at the venous end of the capillaries. Increase in blood osmotic pressure decreases the reenty of fluid into blood. Thus, more interstitial fluid accumulates at the tissue spaces.

E. Increased blood hydrostatic pressure exerts more pressure on the capillary walls, enables more cell free plasm to enter into tissue spaces.

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