Urokinase-type Plasminogen Activator (uPa) is a serine endopeptidase. The active

Question

Urokinase-type Plasminogen Activator (uPa) is a serine endopeptidase. The active site of this peptidase binds the peptide-motif Ser-Gly-Arg-Ser-Ala and cleaves the protein/peptide between arginine and serine. What is the sequence of the products of the oligopeptide Ala-Gly-Ser-Gly-Arg-Ser-Ala-Lys-Gly-Ala-Ser-Asp after cleavage by uPa? Ala-Gly and Ser-Gly-Arg-Ser-Ala-Lys-Gly-Ala-Ser-Asp Ala-Gly-Ser-Gly-Arg and Ser-Ala-Lys-Gly-Ala-Ser-Asp Ala-Gly-Ser-Gly-Arg-Ser-Ala-Lys-Gly-Ala-Ser and Asp Ala-Gly-Ser-Gly-Arg-Ser and Ala-Lys-Gly-Ala-Ser-Asp

Explanation / Answer

As uPa binds to the peptide motif Ser-Gly-Arg-Ser-Ala and cleaves it between Arg and Ser,

Ala-Gly-Ser-Gly-Arg-Ser-Ala -Lys-Gly-Ala-Ser-Asp ---->uPa---->Ala-Gly-Ser-Gly-Arg + Ser-Ala -Lys-Gly-Ala-Ser-Asp(option b)

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