A 52-year woman with a history of systemic hypertension and chronic renal failur

Question

A 52-year woman with a history of systemic hypertension and chronic renal failure undergoes kidney transplatation, but the graft fails to produce urine. A renal biopsy is diagnosed as "hyperacute transplant rejection." Graft rejection in this patient is caused primarily by which of the following mediators of immunity and inflammation?

1. Cytotoxic T lymphocytes

2. Helper T Lymphocytes

3. Mononuclear phagocytes

4. Natural killer (NK) cella

5. Preformed antibodies

I tried 1&3 and they are both wrong....please help!

Explanation / Answer

Answer:

1. Cytotoxic T lymphocytes

Graft rejection is primarly caused the T-cells and the mononuclear monocytes. the mismatching of the tissue grafting will lead to secretion of theantibodies suchas the T-cells and mononuclear monocytes. These cell act on the foreign tissue and cause inflammation .

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