A. Synthesis 1. Mass of salicylic acid (g) 2. Theoretical yield of aspirin (g) C

Question

A. Synthesis 1. Mass of salicylic acid (g) 2. Theoretical yield of aspirin (g) Calculation for Theoretical Yield of aspirin: 3. Experimental Yield of aspirin (g) 4. Percent Yield, based only on mass (%) Aspirin (80.2 g/mol) is prepared by reacting salicylic acid (138.1 g/mol) with acetic anhydride (102.1 g/mol) according to the reaction scheme seen in figure 2. However, often in organic synthesis a sample is not completely pure due to side reactions or residual reactants found in your product. Once the aspirin is synthesized in this experiment, we will attempt to quantitate the percent yield and the purity of the aspirin through the use of an acid-base titration.

Explanation / Answer

Salicylic aicd + Acetic anhydride ------------> Aspirin + acetic acid

Mass of salicylic acid = 2.001 g.

Molar mass of salicylic acid = 138.1 g/mol

Number of moles of salicylic acid = mass / molar mass = 2.001 / 138.1 = 0.0145 mol

From the balanced equation,

1 mol salicylic acid froms 1 mol aspirin

then, 0.0145 mol salicylic acid forms 0.0145 mol aspirin

Therefore, theoretical yield of aspirin = 0.0145 * 180.2 = 2.613 g.

% Yield = (Actual yield / Theretical yield) * 100 = (1.103 / 2.613) * 100 = 42.2 %

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