(a) If individuals A and B have a child, what is the probability that the child
ID: 52288 • Letter: #
Question
(a) If individuals A and B have a child, what is the probability that the child will have the disease? HINT: It helps to first assign genotypes to all individuals in the pedigree. For individuals where several genotypes are possible, use the information in the pedigree to calculate the probability of each possible genotype.
(b) If individuals C and D have a child, what is the probability that the child will have the disease?
(c) If the first child of C * D is normal, what is the probability that their second child will have the disease?
(d) If the first child of C * D has the disease, what is the probability that their second child will have the disease?
Explanation / Answer
(a) If S = unaffected , s = effected, B male can be Ss, and female
A will have 2/ 3 chance of being Ss.
so, chance of an affected child is 1 x 2/ 3 x 1/ 4 = 1/ 6.
(b) C' s mother A is heterozygous and C has a 1/ 2 chance of being heterozygous. D' s
mother can be heterozygous, D a 1/ 2 chance of heterozygosity.
chance of an affect ed child is 2/ 3 x 1/ 2 x 1 x 1/ 2 x 1/ 4 = 1/ 24.
(c) probability can be 1/ 24.
(d) The chance of the second child being ss is 1/ 4.
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