using the paper \"Nourishing the aging brain\" by morten scheibyeknudsen. It was
ID: 51895 • Letter: U
Question
using the paper "Nourishing the aging brain" by morten scheibyeknudsen. It was published in The Scientist,an open access science megazine. You find it at www.the-scientist.com/. the issue is March 1,2015 page 47. Answer:
1) how does a restricted calorie diet help glucose homeostasis and which other benefits to health it peovides?
2)which neurodegenerative conditions benefit from a reduced calorie diet? Is there a neurodegenerative disease which does not?ehy?
3) Are there any benefits to the brain from a high fat diet? Explain comparing chemical structures/species.
Explanation / Answer
1) A restricted calorie diet helps gluocose homeostasis by improving glucose tolerance, decreasing insulin secretion and inreasing insulin sensitivity in the peripheral tissues. Insulin is a peptide hormone secreted by the beta cells of pancreas. It regulates the metabolism of carbohydrates and fats by promoting the absorption of glucose to the skeletal muscles and fat tissue and causes the fats to be stored rather than being used for energy.
2) According to the paper there are clear evidences that dietary intake does affect neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's etc, but the exact mechanism is not known. However, Amylotropic Lateral Sclerosis (ALS) in fact does not benefit from reduced calorie diet. Caloric restriction exacerbates the progression of ALS. The most probable reason may be a failure to meet the neuronal energy requirement in ALS which leads to the loss of motor neurons.
3) Brain can use ketones instead of glucose as an alternative energy source. These are metabolites which are synthesized from fatty acids in the liver.
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