I need help with instrumental chemistry MS-1: What does a mass spectrometer prod

Question

I need help with instrumental chemistry MS-1: What does a mass spectrometer produce and measure? What property does mass spectrometer use to identify different species? Ms Listthe five massanalyzers discussed during the lecture. Point out which two can achieve a mass resolution above 105. MS3: What are the four ionization methods discussed during the lecture?aassily them into hard and soft ionization methods. Ms-: In the El mass spectrum ofiso-butanol which peak corresponds to the molecular ion peak (C4Hioo 2) What neutral molecule may be lost from the molecular ion and produces which peak? G) Whatis the exact of C ERC Ha "o and Ca Hs2D "o? What isthe resolution needed to separate these two peaks in mass spectrum? MASS SPECTRUM isotope 2014101787 0015 13.00335484 11 15.99491464 99.762. 0.0 15 300 45 60 75 17999 5939 02 miz

Explanation / Answer

Answer to MS1)

Mass spectrometry is a powerful analytical technique. It is used to identify molecules, impurities in a sample and the structure and chemical properties of different molecules. The mass spectrometer produces gaseous ions from the sample under investigation. These gaseous ions can be positive or negative and with or without fragmentation. It then separates these ions based on specific mass-to-charge ratios (m/z) and then records the relative abundance of each ion type.

Answer to MS2)

The mass analyser separates the ions produced by a mass spectrometer. The six general types of analysers are:

(1) Quadrupole Mass Analyser (2) Time of Flight Mass Analyser (3) Magnetic Sector Mass Analyser (4) Electrostatic Sector Mass Analyser (5) Ion Trap Mass Analysers (6) Fourier transfer Ion Cyclotron Resonance

Mass resolution is the ratio of the observed m/z value to the smallest difference in m/z for two ions that can be separated and is can be expressed as (m/z) / (m/z)

A new generation of high resolution ion trap mass analyser called Orbitrap can reach a resolution of 106 at m/z = 200. Orbitraps have high sensitivity, high precision and a good dynamic range and find applications in proteomics, metabolomics, and food and safety analysis. Fourier transfer Ion Cyclotron Resonance and Sector magnet analysers can also achieve the resolution of above 105.

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