1. Aspirin can be prepared by the reaction of salicyue acid, and acetic acid or
ID: 516066 • Letter: 1
Question
1. Aspirin can be prepared by the reaction of salicyue acid, and acetic acid or acetic anhydride, which one favored and why? 2. In the compound shown below, identify the acyL corbomu and carboxyl groups CH, CH2-C-OH 3. Shows using a reaction equation, how we can produce Propyl-o bromobenzoate from o brown obenzoic acid 4. Acid chlorides react with water to yield carborylic acids show the following: The reaction b. The intermediates c The energy diagram mechanism involved Write the equation, including intermediates, for the reaction between ammonia, NH3), and 2-methyl propanoyl chloride, CH3 CH-0-cu), to yield 2- methy upropanamideExplanation / Answer
Ans 1. The preparation of salicylic acid with acetic anhydride is favoured. Because if the reaction is carried out with acetic acid using an acid catalyst, the product is ester which can be hydrolysed in the presence of excess water produced by reaction itself. The reaction goes in backward / reverse direction that leads to decrease in yield of aspirin.
Whereas acetic anhydride poses no such problems. It is cheap, common and quite stable in normal conditions and the aspirin can be easily extracted by recrystallisation. The reaction gives good yield of products and hence preferred.
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