Q.12: A protein Max has the footprint-GAACAGCC----40----GAACAGCC a. Which of the

Question

Q.12: A protein Max has the footprint-GAACAGCC----40----GAACAGCC

a. Which of the following could apply to Max binding?
A. Zinc-finger binds direct repeat as a monomer
B. Helix-loop-helix binds direct repeat as a monomer
C. Helix-loop-helix binds direct repeat as a dimer
D. Leucine Zipper binds direct repeat as a monomer
E. Leucine Zipper binds direct repeat as a dimer
F. A, B, and D
G. A, C, and E

b. Assume Max contains a sequence, CxxxC-(x23)-HxxH. Mutation ofHis to Ala abolishes transcription, but replacement with Cys stillmaintains some activity.
A. Max is a Zn-finger
B. The Ala mutation perturbs coordination of Zn and abolishesactivity
C. The His --> Cis mutation does not completely abolishcoordination of Zn
D. All of the above

Explanation / Answer

F. A, B, and D D. All of the above

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