Which of the following statements is/are true about cell-cell signaling in devel

Question

Which of the following statements is/are true about cell-cell signaling in development, when given a certain concentration of ligand?

a. The extracellular matrix cannot induce the activation of an intracellular signaling pathway

b. If the DNA, mRNA and protein products of two cells are identical, they can still respond differently to an extracellular ligand binding a receptor on their surface.

c. All growth factors work through a single cell signaling pathway

d. Phosphorylation of an intracellular receptor upon binding of the receptor with its ligand is one of the common mechanisms used by multiple cell signaling pathways.

e. The binding of a ligand to its receptor cannot result in the inhibition of other proteins associated with that receptor

Explanation / Answer

The statement A and D is true about cell-cell signaling in development, when given a concentration of ligand. Since cell signaling is receptor mediated the extracellular matrix cannot induce the activation of an intracellular signaling pathway unless the receptor is bound with the specific ligand, and phosphorylation of an intracellular receptor upon binding of the receptor with its ligand is the common mechanism used by cell signaling pathway. All the other statements given above are not true.

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