Which of the following statements about glutathione (GSH) are true? There is mor

Question

Which of the following statements about glutathione (GSH) are true? There is more than one correct statement. Check all the true statements.

a. GSH prevents oxidative damage in brain cells.

b.Glutathione conjugation to a toxic substance, such as a halogenated alkene, results in a less polar molecule.

c. GSH is necessary for protein synthesis. d. GSH plays a role in the transport of amino acids across membranes.

e.The sulfhydryl group of GSH can reduce peroxides.

f. The glutamate residue of GSH can accept H and e– from radicals.

Explanation / Answer

a. GSH prevents oxidative damage in brain cells. This statement is true. GSH acts as an antioxidant and thus prevents fatty-acid induced oxidative stress in human brain vascular endothelial cells.

c. GSH is necessary for protein synthesis. This statement is true.

d. GSH plays a role in the transport of amino acids across membranes. This statement is true. GSH plays a vital role in translocation of amino acids across membrane by binding to the glutamate recognition site of the NMDA and AMPA receptors.

e. The sulfhydryl group of GSH can reduce peroxides. This statement is true. Reduced glutathione contains a cystein residue which reduces the oxidized form of the enzyme glutathione peroxidase, which in turn reduces Hydrogen Peroxide (H2O2).

Related Questions

Navigate

• Browse (All)
• Browse W
• Subjects

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.