Multidrug resistance can make it difficult to treat cancer successfully with che

Question

Multidrug resistance can make it difficult to treat cancer successfully with chemotherapy. What causes multidrug resistance in cancer cells? Transmembrane proteins actively pump chemotherapy drugs and other toxins out of cancer cells. The immune system eventually produces antibodies to each chemotherapy drug that destroy the drugs. The smooth endoplasmic reticulum in some cancer cells neutralizes a variety of chemotherapy drugs. Some cancer cells phagocytize chemotherapy drugs and use the lysosomes in the cell to destroy the drugs.

Explanation / Answer

option 1 is correct

transmembrane proteins actively pumpchemotherapy drugs and other toxins out of cancer cells. multidrugs resistance is the active efflux of drugs by ATP-binding cassette transporters. in this process energy generate from ATP hydrolysis to actively pump chemotherapy drugs and other toxine across the membrane.

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