Which of the following statements about Vitamin K and GLA domains are true (indi

Question

Which of the following statements about Vitamin K and GLA domains are true (indicate all that are true)

a) Vitamin K is necessary for the g-carboxylation of glutamic acid residues in GLA domains

b) Negatively charged side-chains in GLA domains attach clotting factors to cell membranes via interactions with positively charged polar head groups in lipids such as choline

c) Negatively charged side-chains in GLA domains attach clotting factors to cell membranes via interactions with Ca+2 ions that also interact with phospholipids

d) The ability of Vitamin K to react with molecular oxygen, generating a strong base as an intermediate, is crucial to its activity

e) Vitamin K is an eicosanoid synthesized from arachidonic acid

Explanation / Answer

a) Vitamin K is necessary for the g-carboxylation of glutamic acid residues in GLA domains - True

b) Negatively charged side-chains in GLA domains attach clotting factors to cell membranes via interactions with positively charged polar head groups in lipids such as choline - True

c) Negatively charged side-chains in GLA domains attach clotting factors to cell membranes via interactions with Ca+2 ions that also interact with phospholipids - False

d) The ability of Vitamin K to react with molecular oxygen, generating a strong base as an intermediate, is crucial to its activity - False

e) Vitamin K is an eicosanoid synthesized from arachidonic acid - True

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