The toxicity of a substance is usually given in the form \"LD_50 (method of dosa

Question

The toxicity of a substance is usually given in the form "LD_50 (method of dosage) in (test specie): x mg/kg (of body weight) " For example, for salicylic acid, The Merck Index gives: LD. i.v. in mice: 500 mg/kg. "I.v." means intravenous, by injection into a vein. The LD50 must be known when prescribing medicines; to be effective, their doses often have lo approach levels at which they may become toxic, and the physician has to know what that level is. If salicylic acid toxicity were the same for humans as for mice and a person weighs 132 lbs, u hat percentage would a 10 g dose be of the LD^dose? [Show your calculations.

Explanation / Answer

Patient weighs 132 lbs or 59.87 kgs

So LD50 for this person will be 500× 59.87 = 29935 mg or 29.9grams

If this person is given 10 g of salicylic dose then it will be 10/29.9 = 0.33 or 33% of the LD50 dose for that patient.

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