Further scrutiny of members of this family reveals the following: 1) The disease

Question

Further scrutiny of members of this family reveals the following: 1) The disease’s degree of expression varies among individuals, with some mildly affected, others moderately affected and still others severely affected; and 2) Individual III-14 was previously married. Her ex-husband is phenotypically normal, with no history of the disease in his family going back ten generations. He has custody of the couple’s two children, a girl and a boy, both of whom are affected with the disease. The partial pedigree is shown below (the “slash” represents separation or divorce)

a) autosomal dominant, autosomal recessive, Y linked, X-linked dominant, and X-linked recessive.

b) Do these findings eliminate any of the remaining “likely or unlikely” modes of inheritance listed in part (a)? Are any of these modes of inheritance still possible? If so, which one(s) and why?

c.     Is mitochondrial inheritance a likely, unlikely or an impossible mode of inheritance for this disease? Does it provide an explanation for the disease’s variable expressivity?

d.    How can mitochondrial inheritance explain individual III-14?

Explanation / Answer

Theautosomal dominant means in the next generation both male and female is effected , if only males are geting affected the it is y linked disease then it is called holandric inheritance

but if the next generation doesnot show the disease then it can be a x linked recessive because female might become carrier in the next generation

mitochondiral inheritance is very different , all the individual in the next generation gets effected because mitochondria gets affected and that passes to next generation and shows he disease as in generation 3 and 4.

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