Which of the following statements regarding enzyme inhibators is true? Which of

Question

Which of the following statements regarding enzyme inhibators is true?

Which of the follwoing occurs when the blood becomes more acidic than normal?

8.3 X 107 Carbonic anhydrase 4 x 107 Catalase 2.8 X 108 Crotonase 1.6 X 108 Fumarase A) Acetyl strase B) Carbonic anhydrase C) Catalase D) Crotonase E Fumarase 20. Which of the following statements regarding enzyme inhibitors is true? A reversible inhibitor typically deactivates an enzyme permanently. A) B) Irreversible inhibitors are often structural analogs of substrates or products. D) Reversible inhibitors cannot bind to the free enzyme. E) Potent toxins are generally reversible inhibitors. 21. Which of the following occurs when the blood becomes more acidic than normal? A) pH of the blood rises. B) Hemoglobin adopts the R state. C) Leads to more binding of oxygen to hemoglobin. D) His-146 in hemoglobin becomes deprotonated. E) None of the above

Explanation / Answer

20. A (false, because reversible inhibitors do not undergo any chemical reaction during binding and can be removed by dilution or dialysis.

B. (False, mostly reversible inhibitors are structurally similar to substrate molecule)

C. (false,irreversible inhibitors can also be used as therapeutic drugs)

D. (True, reversible inhibitors can not bind, it does not form any covalent bond with enzyme, can be removed from enzyme easly)

F (False, potent toxins can be irreverible inhibitors also)

21. A. (Not occurs, pH will decrease)

B. (Not occurs, hemoglobin take T - state at low pH)

C. (Not occurs, hemoglobin release oxygen at low pH)

D. (Not occurs, Hist-146 protonated at low pH)

Answer will be E (none of the above)

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