1. What kind of mutation has occurred in the DNA of people with cystic fibrosis?
ID: 49281 • Letter: 1
Question
1. What kind of mutation has occurred in the DNA of people with cystic fibrosis? How does the mutation affect the function of lung cells? Why would individuals that are heterozygous for CF have an advantage over normal individuals?
2. How are mutations inherited? How does the process meiosis differ from mitosis? What mechanisms during meiosis ensure that the genetic material passed on to offspring will be diverse?
3. What's the difference between dominant and recessive alleles? If the mutation that causes a disease is recessive how will it be inherited? Conversely if the mutation is dominant how will it be inherited?
Explanation / Answer
Ans 1 -- It is an autosomal recessive disorder caused by the presence of mutations in both the copies of the gene for the protein CFTR .
symptoms --- difficulty in breathing , coughing sputum as a result of frequent infections . Mucus in the paranasal sinuses is equally thick and may also cause blockage of sinu passages.
Those with a single working copy are carriers and otherwise mostly normal .
ans 2 Hereditary mutations are inherited from a parent and are present throughout a person’s life in virtually every cell in the body. These mutations are also called germline mutations because they are present in the parent’s egg or sperm cells, which are also called germ cells. When an egg and a sperm cell unite, the resulting fertilized egg cell receives DNA from both parents. If this DNA has a mutation, the child that grows from the fertilized egg will have the mutation.
Crossing over mechanism.
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