some bio chrmistry questions 1) Which of these is NOT true about the active site

Question

some bio chrmistry questions

1) Which of these is NOT true about the active site of an enzyme?

   a.   It is composed of distinct amino acids that perform catalytic activities

   b.   It often has a cofactor depending on the enzyme

   c.   It is formed by the folding of the protein

   d.   It binds to the substrate covalently

   e.   It can be affected by changes in the primary structure of the protein

2) Which is NOT true about the Km of an enzyme:

   a.   is calculated as half of the maximal velocity of an enzyme

   b.   is a hypothetical number that can only be predicted using experimental data

   c.   is negatively affected by a competitive inhibitor

   d.   is a measure of how tightly an enzyme binds to its substrate

   e.   all of the above are true

3) Which is NOT true about Vmax:

   a.   is the maximal velocity at which an enzyme can function

   b.   is reduced by a non-competitive inhibitor

   c.   is determined on a Lineweaver-Burke plot by taking the reciprocal of the y-intercept

   d.   is low for an enzyme with a low Km and high substrate affinity

   e.   can be determined by multiplying the Km by 2

Explanation / Answer

1). a.   It is composed of distinct amino acids that perform catalytic activities ---> TRUE

   b.   It often has a cofactor depending on the enzyme -------> TRUE

   c.   It is formed by the folding of protein -------> TRUE

   d.   It binds to the substrate covalently ---------------> FALSE (Enzymes bind to their substrates through non-covalent interactons).

   e.   It can be affected by changes in the primary structure of the protein --------> TRUE (Cahnge in amno acid sequence affects active site functioning)

2)

   a.   is calculated as half of the maximal velocity of an enzyme -------> TRUE

   b.   is a hypothetical number that can only be predicted using experimental data -----> TRUE

   c.   is negatively affected by a competitive inhibitor --------> FALSE competitive inhibitors raises Km value

   d.   is a measure of how tightly an enzyme binds to its substrate -----------> TRUE

   e.   all of the above are true

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