CHEM 330: Structure and Function of Biomolecules Answer the following questions

Question

CHEM 330: Structure and Function of Biomolecules Answer the following questions concerning a section of double-stranded DNA containing 1000 base pairs. If the DNA contains 28% adenosine residues, how many guanosine residues are in the DNA? Are the nucleotide compositions of each of the two individual strands of DNA identical? Explain. If the DNA is entirely in the B-DNA conformation: What is the length of the DNA? How many helical turns does the DNA contain? If the DNA exists as chromatin, how many nucleosomes should be formed in that section of DNA?

Explanation / Answer

Part 1.

A.) Double stranded DNA follows Chargaff's rule of equivalence which states that number of pyrimidines is equal to number of purines. The amount of Adenine is equal to amount of Thymine and the amount of Guanine is equal to amount of Cytosine.

A+T = G+C

Adenine = 28% Thymine = 28%

A+T = 56%

G+C = 100 - 56 = 44 %

Guanine residues = 22%

B.) The nucleotide compositions of each of the two individual strands of DNA are identical if they obey Chargaff's rule of equivalence.

C.) i.) The length of B- DNA conformation is 20 Angstrom diameter.

ii.) The helical turns contain 10 base pairs per turn.

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