Based on the protein folding funnel theory, what would happen to the actual funn
ID: 48802 • Letter: B
Question
Based on the protein folding funnel theory, what would happen to the actual funnel (shape, kinetic traps, etc) if there was an increase in temperature. (Not the protein folding change, but the specific change to the funnel)Secondly, how do you account for water?
Thank you! Based on the protein folding funnel theory, what would happen to the actual funnel (shape, kinetic traps, etc) if there was an increase in temperature. (Not the protein folding change, but the specific change to the funnel)
Secondly, how do you account for water?
Thank you!
Explanation / Answer
At the high temperatures the landscape is "smooth" and the protein has sufficient energy to explore many conformational states.
Protein folding is been driven by its interface with H2O as it comes out from ribosomal synthesis into the the bulk aqueous phase of the cytoplasm. This mainly involves the interactions which are hydrophobic , therefore , reducing their big surface area with H2O which otherwise should cause an opposed entropy decrease .
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