1. Genes that encode components of the cytoskeleton and extracellular matrix oft
ID: 48645 • Letter: 1
Question
1. Genes that encode components of the cytoskeleton and extracellular matrix often contribute to which process?
Select one:
a. Signal transduction
b. Metastasis
c. Primary tumor formation
d. Mutation
e. DNA repair
2. In Burkitt lymphoma patients, despite translocation, the oncogene c-MYC remains nearly intact in its new location. Yet c-MYC is believed to be responsible for the lymphoma because:
Select one:
a. The c-MYC DNA sequence undergoes several point mutations
b. the c-MYC gene is placed under the control of B-cell-specific gene regulatory sequences and is highly expressed.
c. The c-MYC gene is released from inhibition by miRNAs.
d. The c-MYC DNA sequence undergoes hypermethylation.
e. the c-MYC DNA sequence is nearly intact but is inverted in the new position.
3. Which of the following result(s) directly from metastasis?
Select one:
a. Primary tumors
b. Decreased DNA repair
c. Secondary tumors
d. Tumor vascularization
e. Increased apoptosis
4. Which of the following best characterizes many cancers such as colon cancer?
Select one:
a. They result from the activation of one critical tumor-suppressor gene
b. They result from a series of sequential mutations in a number of genes.
c. They result from decreased expression in a series of cellular oncogenes
d. They result when the transition from G2 to M in the cell cycle is inhibited
e. They result when DNA replication during the S period of the cell cycle is inhibited
5. A rare situation where only one of the two copies of a particular tumor-suppressor gene needs to be inactivated before there is a progression toward cancer would be called?
Select one:
a. Clonal evolution
b. Haploinsufficiency
c. Aneuploidy
d. Loss of heterozygosity
e. Signal transduction
Explanation / Answer
1.b. Metastasis
3. Secondary tumors
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