Who was the person who first observed the disorder calledAlzheimer’s Disease(AD)
ID: 48428 • Letter: W
Question
Who was the person who first observed the disorder calledAlzheimer’s Disease(AD)?
In what year and country were the observations made?
Why did the patient, AugusteDeter, a 51 year old woman, say about her condition, “I have lost myself”?
What are thetwo hallmarksof changes in the brain of Alzheimer’s sufferers?
“Of the top 10 causes of death in America - Alzheimer’s is now No. 6 — it is the only one for which there is no way to prevent it, cure it, or even slow its progression.” Therefore, Biogen is excited that its new medication can act in two ways against the devastation of this brain disorder. Name thetwo-points of attack that Biogen’s drug hason this disease.
State the number of different drugs had been developed by drug companies to treatAlzheimer’s Diseaseduring the period from 2002 through 2012.
Of these, how many had received approval by the Food and Drug Administration (FDA), aside from the 14 that are still being tested in clinical trials?
Look at the colored transverse sections of PET scans taken before and after the administration of Biogen’s drug,aducanumab(nicknamed “adu”). What is noteworthy about the right image versus the left image?
What dobeta-amyloid plaquesandneurofibrillary tanglesforming in the brain tissue actually do to the brain tissue in AD sufferers?
What is theonlyway to determine if the diagnosis of AD was correct?
Goldman Sachs analysts have pegged future peak annual sales ofadu—which even in the best-case scenario was years away from approval - is what dollar figure,per year?
What is theamyloid hypothesis,and what happens under this ‘educated guess’ about the progression of AD?
What wassemagacestat?
Who manufactured this drug?
What happened in AD patients duringsemagacestat’sclinical trial?
Page Break
Who are “theBAPtists” and “thetauists” among AD researchers?
How did their nicknames evolve?
Is either group’s approach any better than the other’s?
How did AjayVerma“modernize” the Alzheimer screening process (tough to do in living AD patients) to better proceed with clinical trials?
Why didVermahave to screen the AD ‘potential’ patients?
Why did Biogen refer kindly toVermaas “Q” [HINT: James Bond]?
How many years in advance of symptomsdoesbeta amyloid begin developing in an AD patient’s brain?
As a consequence of this fact, what was one reason that researchers believed might explain why the AD drugs they were giving for beta amyloid were not working?
What is your “take” on this article, in other words, what kinds of insight do you now have about the “big business” of drug research and production? Why are thesebusinessnot always successful with manufacturing these drugs?
Explanation / Answer
The first person to have observed Alzheimer's disease was Dr. Alois Alzheimer.
The observations were made in year 1906 in Germany.
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