Tightly packaged cellular DNA is supercoiled. and most DNA is negatively superco

Question

Tightly packaged cellular DNA is supercoiled. and most DNA is negatively supercoiled. Identify the true statements about negative supercoiling in DNA. Negative supercoiling occurs as a result of the underwinding of circular or protein-bound DNA. Supercoiling permits the compacting of DNA. Negative and positive supercoiling give rise to mirror image helices with similar functional characteristics. Negative supercoiling helps in strand separation during replication and transcription. Negatively supercoiled DNA has fewer base pairs per turn than relaxed DNA.

Explanation / Answer

Do NOT choose:

- Negatively supercoiled DNA has fewer base pairs per turn than relaxed DNA

- Negative + Positive supercoiling give rise to mirror image helices with similar functional characteristics

Choose (TRUE)

- Negative supercoiling occurs as a result of the underwinding of circular or protein-bound DNA

- Negative supercoiling helps in strand separation during replication and transcription

- Supercoling permits compacting DNA

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