DIRECTIONS: Complete all questions. You have plenty of time. First make an outli

Question

DIRECTIONS: Complete all questions. You have plenty of time. First make an outline of your response on your own, organize your calculations and reasoning and only then, write down a response on the homework sheet You must be clear and concise. Always show your calculations in and organized manner. Your reasoning should be explained clearly and briefly. You have plenty of space; do not feel like you have to use it all! Because calculations are involved, you are allowed to us handwriting. Make sure it is readable. Question Dr John Merrick is characterizing a protein from agene that he cloned from a frozen mammoth protein). To characterize oBP, he decided to compare its o2 binding ability with that of elephant hemoglobin. He did the experiment at normal pH 7 and at high pH 9. Mammoth OBP (pH-70 Elephant Hb (pH 7) 1 OO 75 lephant Hb (pH 9) 25 1o 2O oxygen partial prossure (mnm Hg) Note that 02 being a gas, its "concentration is not measured in molarity. It is measured as a pressure and the units are "mm Hg" (referring to old barometer usage). You can use this unit in your discussion, just treat it like a concentration. a) (2 pts) Dr Merrick concludes that mammoth oBP has a higher affinity for oygen than elephant hemoglobin at normal pH Is he correct? Justify your response.

Explanation / Answer

(a). No, at normal pH mammoth OBP does not have a higher affinity for oxygen than elephant hemoglobin. It is because as it is clear that at ph = 7, the concentration of oxygen in Elephant Hb is greater than mammoth OBP for every saturation state.

(b). When pH is changed from 7 to 9, the protein of mammoth is affected the most because there can be seen a large change in the oxygen concentration in the mammoth OBP as compared to the elephant Hb.

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