A normal woman who has a colorblind (but otherwise normal) father, marries a man
ID: 48223 • Letter: A
Question
A normal woman who has a colorblind (but otherwise normal) father, marries a man who has factor VII hemophilia. Their first son has Duchenne's Muscular Dystrophy.
Describe precisely what kind of events could cause each of the following in a child of theirs.
a) An normal appearing son who is heterozygous for factor VIII hemophilia and has Klinefelter's syndrome
b) A colorblind daughter with Turner syndrome.
c) A daughter with Turner syndrome and factor VIII hemophilia
d) A son with Klinefelter's syndrome who has Duchenne's muscular dystrophy
P.S. I think my teacher is looking for answers such as deletion, duplication, inversion, etc.
Explanation / Answer
a) At meiosis there is nondisjuction of X chromosome
b) Females are XX. This happened due to the translocation of SRY (sex determining region Y) to an autosome of a 46, XX individual
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