under anaerobic conditions, i.e. during vigorous exercise, when hemoglobin is no

Question

under anaerobic conditions, i.e. during vigorous exercise, when hemoglobin is not able to supply adequate amounts of oxygen to your tissues, your muscles accumulate lactate derived pyruvate. This reaction is very favorable, thus the reversal would not be favorable. However, in the liver the reaction can easily be reversed and lactate can serve as a substrate for gluconeogenesis. Explain how this is accomplish under anaerobic conditions, i.e. during vigorous exercise, when hemoglobin is not able to supply adequate amounts of oxygen to your tissues, your muscles accumulate lactate derived pyruvate. This reaction is very favorable, thus the reversal would not be favorable. However, in the liver the reaction can easily be reversed and lactate can serve as a substrate for gluconeogenesis. Explain how this is accomplish under anaerobic conditions, i.e. during vigorous exercise, when hemoglobin is not able to supply adequate amounts of oxygen to your tissues, your muscles accumulate lactate derived pyruvate. This reaction is very favorable, thus the reversal would not be favorable. However, in the liver the reaction can easily be reversed and lactate can serve as a substrate for gluconeogenesis. Explain how this is accomplish

Explanation / Answer

Gluconeogenesis is the process of formation of glucose from non carbohydrate sources such as pyruvate, lactate in liver. It help in hypoglycemic conditions. Gluconeogenesis occurs during fasting, low-carbohydrate intake or intense exercise.

Lactate produced during anaerobic conditions diffuses out of blood cells and is transported to liver where it is converted into pyruvate by Cori cycle with the help of enzyme lactate dehydrogenase. This pyruvate is cs now converted into glucose by gluconeogenesis. This cori cycle also helps in preventing lactic acidosis. Thus cori cycle helps in reutilising lactate and generating glucose from it.

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