obtain 10 mmol of phenol and dissolve it in a minimal amount of ethanol (-10 mL
ID: 479925 • Letter: O
Question
obtain 10 mmol of phenol and dissolve it in a minimal amount of ethanol (-10 mL in Add round-bottom fl M KoH in ethanol and swirl the mixture to fully combine 1.2 mL of benzyl chloride and a boiling chip and reflux the mixture for30 minutes At the completion of the reflux remove the heat and add about 20 mL of water to the flask. Transfer material to a the mL and add 20 mL of methyl tert-butyl ether to the round-bottom flaskeswirl and add this ether solution to the separatory funneleshake, vent, and allow the to separate eparate the aqueous and organic layers into separate, labeled beakers and return the aqueous layer to the separatory funnel Extract the aqueous layer with an additional 20 mL of methyl tert-butyl ether and remove the aqueous layer to a beakerf Add the first ether solution to the second and wash the combined organic solutions with 20 mL of brine solutio Remove the aqueous layer and transfer the organic layer to a 125 mL Erlenmeyer flask and dry with magnesium sulfate. Magnesium sulfate requires several minutes to fully organic solvents. Swirl the solution periodically while cleaning your glassware tyAfter several minutes gravity filter the remaining ethereal solution to a clean 100 hen ether stops distilling off, mL round-bottom flask, add a boiling chip, and distill off the eth remove the flask from the heating mantle and cool the flask in an ice water bath.Explanation / Answer
3. Extraction of electrophilic aromatic alkylation reaction mixture
Organic layer (methyl t-butyl ether) would contain O-benzylated phenol.
Aqueous layer would contain KCl salt
Extraction of aqueous layer with methyl tert-butyl ether would result in the product going into the organic layer and salt remaining in the aqueous layer. Organic layer is washed with brine to remove water and dried over MgSO4 (anhydrous) before removing solvent on rotavap.
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