PLEASE SHOW ALL WORK/CALCULATIONS! 1. (4 Points) Assuming a blood volume of 5 L

Question

PLEASE SHOW ALL WORK/CALCULATIONS!

1. (4 Points) Assuming a blood volume of 5 L (typical for a 70 kg adult), calculate the total amount (in mg) in the plasma (i.e., in 5 L) if the plasma glucose is at a concentration of 5 mM. The molecular weight of glucose is 180.

2. (1 Point) Next, provide a representation of this amount using common kitchen measures (e.g., 34 Cup, 4 Tablespoons, 14 teaspoon, etc.).

3. (3 Points) A relatively normal plasma glucose rate of clearance for a 70 kg adult is about 2.13 mg/kg/min. If the plasma glucose is maintained at 5 mM, how long (in hours) would it take before glycogen stores would be utilized.

4. (2 Points) Lastly, calculate the net glucose export from the liver (in grams/hr) required to maintain a plasma glucose of 5 mM with a clearance rate of 2.13 mg/kg/min.

Explanation / Answer

Q1.

Calculate total mass of glucose in Plasma if..

M = 5 mM = 5*10^-3 M

First..

mol = MV = 5*(5*10^-3) = 0.025 mol of glucose in 5 Liters

mass = mol*MW = 0.025*180 = 4.5 g of glucose

1 g = 1000 mg

so

mg of glucose in plasma (5L) = 4.5*1000 = 4500 mg of glucose

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