Prontosil (structure below) is one of the earliest anti bacterial compounds. It
ID: 478093 • Letter: P
Question
Prontosil (structure below) is one of the earliest anti bacterial compounds. It was observed that prontosil has the desired effect when administered to a live animal, however, it is ineffective if applied directly to bacterial culture. Provide an explanation for these results. Methadone (structure below) is an opioid drug administered for the treatment of pain. Using SAR arguments, rationalize, why it binds to opioid receptors in a manner similar to morphine. Which of the following does not bear an isosteric relation with the other members of the group? a. CH3, NH, OH, F, CI b. CH_2, NH, O, SH, PR (R = alkyl)Explanation / Answer
Methadone binds to the receptor site and blocks other substances to bind to it. Opioid is a 3D T-shaped configuration and two of its branch in T is hydrophobic structure and a methylated nitrogen charged at physiological pH. The charged nitrogen is responsible for activity and is present in one of the hydrophobic planes. A hydroxyl group at one carbon atom in the other plane is present. These block any substance to bind with the receptor site and cause respiratory problems, analgesia, gastrointestinal spasm, etc.
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